A therapeutic medical garment having a variable pressure profile along its length, and including a knitted tubular body and a knitted anti-slip portion formed proximate one end of the tubular body with an inner surface adapted for residing against a wearer's skin. The knitted anti-slip portion includes at least first, second and third yarns simultaneously knitted to form a repeat having a raised surface texture on the inner surface of the anti-slip portion. One of the first, second and third yarns is a low-friction yarn, and two of the first, second and third yarns are high-friction yarns knitted to reside on and form the raised surface texture on the inner face of the anti-slip portion. A fabric construction and a method of forming a fabric construction are also disclosed.