An oral screening toothbrush is provided for screening for oral diseases such as oral cancer and dental caries. The toothbrush emits blue light into the oral cavity and captures an image of the reflection of blue light. Image processing techniques are used to analyze the images to screen for oral diseases. Further, the toothbrush is comprised in a system including a data transfer medium (i.e. “smartphone”) and the Cloud, which allows for data transfer between multiple platforms from the toothbrush. The oral screening toothbrush and extended system provide for in-home oral screening and interaction with health professionals.