Invention Grant
- Patent Title: Reduction of flake-like aggregation in nanoparticulate active agent compositions
- Patent Title (中): 降低纳米颗粒活性剂组合物中的片状聚集
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Application No.: US14133191Application Date: 2013-12-18
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Publication No.: US09345665B2Publication Date: 2016-05-24
- Inventor: Niels P. Ryde , Peter Snyder , Wei Liu , David M. Slifer
- Applicant: Alkermes Pharma Ireland Limited
- Applicant Address: IE Dublin
- Assignee: Alkermes Pharma Ireland Limited
- Current Assignee: Alkermes Pharma Ireland Limited
- Current Assignee Address: IE Dublin
- Agency: Foley & Lardner LLP
- Main IPC: A61K9/10
- IPC: A61K9/10 ; A61K9/00 ; A61K9/14 ; A61K31/5415 ; A61K47/02 ; A61K47/10 ; A61K47/26 ; A61K47/28 ; A61K47/32
Abstract:
This invention is directed to reduction of flake-like aggregation in nanoparticulate compositions. Also encompassed by the invention are compositions comprising a nanoparticulate active agent, at least one surface stabilizer and a flake-like aggregation reducing agent, such as a buffer and a sugar. The nanoparticulate active agent compositions comprise particles of the active agent having an effective average particle size of less than about 2000 nm.
Public/Granted literature
- US20140105984A1 REDUCTION OF FLAKE-LIKE AGGREGATION IN NANOPARTICULATE ACTIVE AGENT COMPOSITIONS Public/Granted day:2014-04-17
Information query
