Invention Grant
US09345699B2 Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling
有权
异喹啉，喹啉和喹唑啉衍生物作为刺猬蛋白信号传导的抑制剂
- Patent Title: Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling
- Patent Title (中): 异喹啉，喹啉和喹唑啉衍生物作为刺猬蛋白信号传导的抑制剂
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Application No.: US13376813Application Date: 2010-06-09
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Publication No.: US09345699B2Publication Date: 2016-05-24
- Inventor: Chunlin Tao , Xiaowen Sun , Hongna Han , Lukasz Koroniak , Neil Desai
- Applicant: Chunlin Tao , Xiaowen Sun , Hongna Han , Lukasz Koroniak , Neil Desai
- Applicant Address: US CA Culver City
- Assignee: NantBioScience, Inc.
- Current Assignee: NantBioScience, Inc.
- Current Assignee Address: US CA Culver City
- Agency: Leydig, Voit & Mayer, Ltd.
- International Application: PCT/US2010/037986 WO 20100609
- International Announcement: WO2010/144586 WO 20101216
- Main IPC: C07D217/16
- IPC: C07D217/16 ; A61K31/472 ; A61K31/47 ; A61K31/517 ; C07D239/74 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D407/12 ; C07D409/12 ; C07D413/12 ; C07D413/14 ; C07D417/12 ; C07D417/14 ; C07D471/04
Abstract:
The invention provides isoquinoline, quinoline, and quinazoline derivatives to treat a variety of disorders, diseases and pathologic conditions, and more specifically to the use of isoquinoline, quinoline, and quinazoline derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds to the treatment of hyperproliferative diseases and pathologic angiogenesis.
Public/Granted literature
- US20120270858A1 Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling Public/Granted day:2012-10-25
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