Invention Grant
- Patent Title: Inhibitors of influenza viruses replication
- Patent Title (中): 流感病毒复制抑制剂
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Application No.: US14305393Application Date: 2014-06-16
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Publication No.: US09345708B2Publication Date: 2016-05-24
- Inventor: Paul S. Charifson , Michael P. Clark , Upul K. Bandarage , Randy S. Bethiel , John J. Court , Hongbo Deng , Ioana Davies , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Dylan H. Jacobs , Joseph M. Kennedy , Mark W. Ledeboer , Brian Ledford , Francois Maltais , Emanuele Perola , Tiansheng Wang , M. Woods Wannamaker , Randal Byrn , Yi Zhou , Chao Lin , Min Jiang , Steven Jones , Ursula A. Germann , Francesco G. Salituro , Ann Dak-Yee Kwong
- Applicant: Vertex Pharmaceuticals Incorporated
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agency: Honigman Miller Schwartz and Cohn LLP
- Agent Andrew N. Weber; Jonathan P. O'Brien
- Main IPC: A61K31/4965
- IPC: A61K31/4965 ; C07D401/00 ; A61K31/5377 ; A61K31/506 ; C07D471/04 ; C07D401/10 ; A61K31/55 ; A61K31/553 ; C07D239/30 ; C07D401/04

Abstract:
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
Public/Granted literature
- US20140296201A1 INHIBITORS OF INFLUENZA VIRUSES REPLICATION Public/Granted day:2014-10-02
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