Invention Grant
US09345770B2 Immunogenic tumor associated stromal cell antigen peptides and methods of their use
有权
免疫原性肿瘤相关基质细胞抗原肽及其使用方法
- Patent Title: Immunogenic tumor associated stromal cell antigen peptides and methods of their use
- Patent Title (中): 免疫原性肿瘤相关基质细胞抗原肽及其使用方法
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Application No.: US14358705Application Date: 2012-11-15
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Publication No.: US09345770B2Publication Date: 2016-05-24
- Inventor: Walter J. Storkus , Anamika Bose , Jennifer Lynn Taylor , Xi Zhao , Devin B. Lowe
- Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2012/065327 WO 20121115
- International Announcement: WO2013/074820 WO 20130523
- Main IPC: A61K45/06
- IPC: A61K45/06 ; A61K38/08 ; A61K38/17 ; G01N33/574 ; A61K39/00 ; A61K31/506
Abstract:
Immunogenic peptides from tumor associated stromal cell antigens, including combinations of such peptides, are disclosed herein. In some examples the peptides are useful for methods of eliciting an immune response. In additional examples the peptides are useful for methods of treating cancer. Methods for decreasing vascularization of a tumor using a Protein Delta Homolog 1 (DLK1) protein or a nucleic acid encoding the protein are also disclosed.
Public/Granted literature
- US20140314758A1 IMMUNOGENIC TUMOR ASSOCIATED STROMAL CELL ANTIGEN PEPTIDES AND METHODS OF THEIR USE Public/Granted day:2014-10-23
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