Invention Grant
- Patent Title: Compositions for targeted delivery of siRNA
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Application No.: US14661947Application Date: 2015-03-18
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Publication No.: US09345775B2Publication Date: 2016-05-24
- Inventor: David L Lewis , David B Rozema , Darren H Wakefield
- Applicant: Arrowhead Madison Inc.
- Applicant Address: US WI Madison
- Assignee: Arrowhead Madison Inc.
- Current Assignee: Arrowhead Madison Inc.
- Current Assignee Address: US WI Madison
- Agent Kirk Ekena; Robert Teigen
- Main IPC: A61K9/08
- IPC: A61K9/08 ; A61K9/14 ; C12N15/11 ; C12N15/87 ; A61K47/32 ; A61K48/00 ; A61K47/48
Abstract:
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.
Public/Granted literature
- US20150202298A1 Compositions for Targeted Delivery of siRNA Public/Granted day:2015-07-23
Information query
