A convenience kit, use of which transforms a conventional IV container spiking and dispensing system to a safety system for handling hazardous drugs. The kit provides a spike receiving subsystem which is interposed between a spike of an IV set and a needle-less syringe connector affixed to a hazardous drug containing IV container to provide a closed pathway for delivering the hazardous drugs and to allow for detaching a spent container without exposing the hazardous drugs to a surrounding environment.