The present invention relates to a sterile filling system, and specifically relates to a sterile filling system for on-line particle adding comprising a filling system, characterized in that it further comprises a system for on-line particle adding. The filling system comprises a first AP valve bank and an injection pipe, the first AP valve bank and the injection pipe being in connection with each other; and the system for on-line particle adding comprises a second AP valve bank, the second AP valve bank being in connection with the injection pipe. The present invention can achieve the object of addition of solid particles during the production of liquid product, and ensure that the finished product will meet the requirement for sterility.