Invention Grant
- Patent Title: Process for the preparation of pyrazole carboxylic acid derivatives
- Patent Title (中): 吡唑羧酸衍生物的制备方法
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Application No.: US14623372Application Date: 2015-02-16
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Publication No.: US09346763B2Publication Date: 2016-05-24
- Inventor: Bjoern Bartels , Fritz Bliss , Katrin Groebke Zbinden , Matthias Koerner
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Little Falls
- Assignee: Hoffman-La Roche Inc.
- Current Assignee: Hoffman-La Roche Inc.
- Current Assignee Address: US NJ Little Falls
- Priority: EP12180802 20120817
- Main IPC: C07D231/14
- IPC: C07D231/14 ; C07C281/04 ; C07C227/16 ; C07C269/04 ; C07C281/02

Abstract:
The present invention relates to a novel process for the preparation of a pyrazole carboxylic acid derivative of the formula wherein R1 is C1-7-alkyl and R3 is C1-7-alkyl which is optionally substituted with halogen or C1-4-alkoxy. The pyrazole carboxylic acid derivative of the formula I can be used as building block in the preparation of pharmaceutically active principles e.g. for compounds acting as phosphodiesterase (PDE) inhibitors, particularly PDE10 inhibitors. PDE10 inhibitors have the potential to treat psychotic disorders like schizophrenia.
Public/Granted literature
- US20150158818A1 PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID DERIVATIVES Public/Granted day:2015-06-11
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