Invention Grant
- Patent Title: Piperidine compound or salt thereof
- Patent Title (中): 哌啶化合物或其盐
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Application No.: US14381814Application Date: 2013-02-27
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Publication No.: US09346787B2Publication Date: 2016-05-24
- Inventor: Tetsuya Sugimoto , Hidekazu Takahashi , Morihiro Mitsuya , Norio Masuko , Hiroshi Sootome
- Applicant: TAIHO PHARMACEUTICAL CO., LTD.
- Applicant Address: JP Chiyoda-ku
- Assignee: TAIHO PHARMACEUTICAL CO., LTD.
- Current Assignee: TAIHO PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP Chiyoda-ku
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2012-043303 20120229; JP2012-186534 20120827
- International Application: PCT/JP2013/055064 WO 20130227
- International Announcement: WO2013/129443 WO 20130906
- Main IPC: C07D417/14
- IPC: C07D417/14 ; A61K31/4545 ; A61K45/06 ; C07D401/14 ; C07D413/14 ; A61K31/337

Abstract:
A novel compound which has an excellent aurora A-selective inhibitory action and is useful as an orally administrable anticancer agent is provided. Also, a novel agent for potentiation of anti-tumor effect of microtubule agonists, which include a taxane anticancer agent, and a combination therapy are provided. A piperidine compound represented by a general formula (I) or a salt thereof: wherein, R1 represents a carboxyl group, —C(═O)NR5R6, or an oxadiazolyl group optionally having a C1-C6 alkyl group or a trifluoromethyl group as a substituent; R2 represents a halogen atom or a C1-C6 alkoxy group; R3 represents a phenyl group optionally having 1 to 3 same or different group(s) selected from a halogen atom, a C1-C6 alkyl group, a C1-C6 alkoxy group, and a trifluoromethyl group as a substituent; R4 represents a hydrogen atom or a C1-C6 alkyl group; and R5 and R6 are the same or different and each represent a hydrogen atom, a C1-C6 alkyl group, or a C3-C6 cycloalkyl group, or R5 and R6 optionally form a 3 to 6-membered nitrogen-containing saturated heterocyclic group together with a nitrogen atom to which R5 and R6 are bound, are provided.
Public/Granted literature
- US20150045342A1 NOVEL PIPERIDINE COMPOUND OR SALT THEREOF Public/Granted day:2015-02-12
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