Invention Grant
US09346803B2 Indomethacin analogs for the treatment of castrate-resistant prostate cancer
有权
吲哚美辛类似物用于治疗阉割抗性前列腺癌
- Patent Title: Indomethacin analogs for the treatment of castrate-resistant prostate cancer
- Patent Title (中): 吲哚美辛类似物用于治疗阉割抗性前列腺癌
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Application No.: US14352421Application Date: 2012-10-17
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Publication No.: US09346803B2Publication Date: 2016-05-24
- Inventor: Lawrence J. Marnett , Andy J. Liedtke , Trevor M. Penning , Adegoke O. Adeniji , Michael C. Byrns
- Applicant: Vanderbilt University , The Trustees of the University of Pennsylvania
- Applicant Address: US TN Nashville US PA Philadelphia
- Assignee: Vanderbilt University,The Trustees of the University of Pennsylvania
- Current Assignee: Vanderbilt University,The Trustees of the University of Pennsylvania
- Current Assignee Address: US TN Nashville US PA Philadelphia
- Agency: Jenkins, Wilson, Taylor & Hunt, P.A.
- International Application: PCT/US2012/060508 WO 20121017
- International Announcement: WO2013/059245 WO 20130425
- Main IPC: C07D209/04
- IPC: C07D209/04 ; C07D209/08 ; C07D231/56 ; C07D471/04 ; C07D209/26 ; C07D209/70
Abstract:
Provided are compositions for inhibiting a biological activity of an aldoketo reductase family 1, member C3 (AKR1 C3) polypeptide. In some embodiments, the compositions are indomethacin derivatives that are AKR1 C3-specific inhibitors. Also provided are methods for producing disclosed indomethacin derivatives that substantially lack cyclooxygenase inhibitory activity but that have AKR1C3 inhibitory activity, methods for inhibiting AKR1C3 polypeptide biological activities, and methods for treating prostate tumors in subjects.
Public/Granted literature
- US20140371261A1 INDOMETHACIN ANALOGS FOR THE TREATMENT OF CASTRATE-RESISTANT PROSTATE CANCER Public/Granted day:2014-12-18
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