Invention Grant
US09346853B2 Synthesis of telaprevir and boceprevir, or pharmaceutically acceptable salts or solvates as well as intermediate products thereof including β-amino acids prepared via Mukaiyama aldol addition
有权
特拉匹韦和波普瑞韦或其药学上可接受的盐或溶剂合物及其中间产物的合成，包括通过Mukaiyama醛醇加成制备的“
- Patent Title: Synthesis of telaprevir and boceprevir, or pharmaceutically acceptable salts or solvates as well as intermediate products thereof including β-amino acids prepared via Mukaiyama aldol addition
- Patent Title (中): 特拉匹韦和波普瑞韦或其药学上可接受的盐或溶剂合物及其中间产物的合成，包括通过Mukaiyama醛醇加成制备的“
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Application No.: US14408465Application Date: 2013-06-19
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Publication No.: US09346853B2Publication Date: 2016-05-24
- Inventor: Kathrin Hoeferl-Prantz , Wolfgang Felzmann , Thorsten Wilhelm , David Benito-Garagorri
- Applicant: Sandoz AG
- Applicant Address: CH Basel
- Assignee: Sandoz AG
- Current Assignee: Sandoz AG
- Current Assignee Address: CH Basel
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: EP12172775 20120620
- International Application: PCT/EP2013/062737 WO 20130619
- International Announcement: WO2013/189980 WO 20131227
- Main IPC: A61K38/04
- IPC: A61K38/04 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00 ; C07K5/107 ; C07D403/12 ; C07K5/087 ; C07K5/083 ; C07K5/062 ; C07C227/02 ; C07C231/02 ; C07C231/12 ; C07C237/06 ; C07F7/18 ; C07K1/10 ; A61K38/00
Abstract:
The invention relates to synthetic routes for preparing telaprevir and boceprevir, and its intermediates as well as peptides other than telaprevir. The synthetic routes are based on a Mukaiyama aldol addition reaction of a silyl enol ether or an enolate with an imine. The invention also refers to novel intermediates for preparing telaprevir/boceprevir or other peptides.
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