Invention Grant
- Patent Title: Expression system
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Application No.: US13627071Application Date: 2012-09-26
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Publication No.: US09346860B2Publication Date: 2016-05-24
- Inventor: Ethel Diane Williamson , Julie Miller , Nicola Jane Walker , Leslie William James Baillie , Paula Thomson Holden , Helen Claire Flick-Smith , Helen Lisa Bullifent , Richard William Titball , Andrew William Topping
- Applicant: THE SECRETARY OF STATE FOR DEFENCE
- Applicant Address: GB Salisbury, Wiltshire
- Assignee: The Secretary of State For Defence
- Current Assignee: The Secretary of State For Defence
- Current Assignee Address: GB Salisbury, Wiltshire
- Agency: Kilpatrick Townsend & Stockton LLP
- Agent Dean W. Russell; Jamie L. Graham
- Priority: GB0016702.3 20000708
- Main IPC: C12N15/70
- IPC: C12N15/70 ; C07K14/32 ; A61K39/00

Abstract:
An immunogenic reagent which produces an immune response which is protective against Bacillus anthracis, said reagent comprising one or more polypeptides which together represent up to three domains of the full length Protective Antigen (PA) of B. anthracis or variants of these, and at least one of said domains comprises domain 1 or domain 4 of PA or a variant thereof. The polypeptides of the immunogenic reagent as well as full length PA are produced by expression from E. coli. High yields of polypeptide are obtained using this method. Cells, vectors and nucleic acids used in the method are also described and claimed.
Public/Granted literature
- US20130164823A1 Expression System Public/Granted day:2013-06-27
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