Invention Grant
- Patent Title: Protein purification methods to reduce acidic species
- Patent Title (中): 蛋白质纯化方法减少酸性物质
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Application No.: US14584492Application Date: 2014-12-29
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Publication No.: US09346879B2Publication Date: 2016-05-24
- Inventor: Natarajan Ramasubramanyan , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Christopher Chumsae
- Applicant: AbbVie, Inc.
- Applicant Address: US IL North Chicago
- Assignee: AbbVie Inc.
- Current Assignee: AbbVie Inc.
- Current Assignee Address: US IL North Chicago
- Agency: McCarter & English, LLP
- Agent Maria Laccotripe Zacharakis; Lisa Tyner
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C12P21/08 ; A61K39/395 ; C07K16/24 ; C07K1/16 ; C07K1/18 ; C12P21/00 ; C07K1/20 ; C07K1/22
Abstract:
The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of charge variants, aggregates, and fragments of a protein of interest, as well as host cell proteins, present in purified preparations by applying particular chromatography conditions during such protein purification.
Public/Granted literature
- US20150141623A1 PROTEIN PURIFICATION METHODS TO REDUCE ACIDIC SPECIES Public/Granted day:2015-05-21
Information query
