Invention Grant
US09347050B2 Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins
有权
能够封闭甘露糖-1-磷酸-6-甘露糖键和去甲基化磷酸化N-聚糖的甘露糖苷酶和促进哺乳动物细胞摄取糖蛋白的方法
- Patent Title: Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins
- Patent Title (中): 能够封闭甘露糖-1-磷酸-6-甘露糖键和去甲基化磷酸化N-聚糖的甘露糖苷酶和促进哺乳动物细胞摄取糖蛋白的方法
-
Application No.: US13876769Application Date: 2011-09-29
-
Publication No.: US09347050B2Publication Date: 2016-05-24
- Inventor: Kathleen Camilla Telesphore Alida Maria Piens , Wouter Vervecken , Albena Vergilieva Valevska , Gwenda Noëlla Pynaert
- Applicant: Kathleen Camilla Telesphore Alida Maria Piens , Wouter Vervecken , Albena Vergilieva Valevska , Gwenda Noëlla Pynaert
- Applicant Address: GB Manchester
- Assignee: Oxyrane UK Limited
- Current Assignee: Oxyrane UK Limited
- Current Assignee Address: GB Manchester
- Agency: Fish & Richardson P.C.
- International Application: PCT/IB2011/002770 WO 20110929
- International Announcement: WO2012/042386 WO 20120405
- Main IPC: C12P19/26
- IPC: C12P19/26 ; C12P21/00 ; A61K38/43 ; C12N15/81 ; C12N9/10 ; C12N9/24 ; A61K38/17 ; A61K38/16 ; A61K38/00
Abstract:
The invention provides mannosidases capable of uncapping mannose-1-phospho-6-mannose moieties and demannosylating phosphorylated N-glycans, methods of using such mannosidases, glycoproteins produced using the methods, as well as methods of facilitating mammalian cellular uptake of glycoproteins.
Public/Granted literature
Information query
