Invention Grant
US09347077B2 Over-expression of a putative oxidoreductase (UcpA) for increasing furfural or 5-hydroxymethylfurfural tolerance
有权
假定氧化还原酶（UcpA）过度表达以增加糠醛或5-羟甲基糠醛耐受性
- Patent Title: Over-expression of a putative oxidoreductase (UcpA) for increasing furfural or 5-hydroxymethylfurfural tolerance
- Patent Title (中): 假定氧化还原酶（UcpA）过度表达以增加糠醛或5-羟甲基糠醛耐受性
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Application No.: US14131468Application Date: 2012-07-09
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Publication No.: US09347077B2Publication Date: 2016-05-24
- Inventor: Xuan Wang , Elliot N. Miller , Lorraine P. Yomano , Keelnatham T. Shanmugam , Lonnie O'Neal Ingram
- Applicant: Xuan Wang , Elliot N. Miller , Lorraine P. Yomano , Keelnatham T. Shanmugam , Lonnie O'Neal Ingram
- Applicant Address: US FL Gainesville
- Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
- Current Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
- Current Assignee Address: US FL Gainesville
- Agency: Saliwanchik, Lloyd & Eisenschenk
- International Application: PCT/US2012/045912 WO 20120709
- International Announcement: WO2013/009679 WO 20130117
- Main IPC: C12P13/00
- IPC: C12P13/00 ; C12P7/56 ; C12P7/46 ; C12P7/10 ; C07K14/245 ; C12N9/02 ; C12P7/06 ; C12P7/16 ; C12P7/18 ; C12P7/40 ; C12P7/44 ; C12P7/54
Abstract:
The subject invention pertains to overexpression of a putative oxidoreductase (ucpA) for increasing furfural tolerance in genetically modified microorganisms. Genetically modified microorganisms capable of overexpressing UcpA are also provided. Increased expression of ucpA was shown to increase furfural tolerance by 50%, and to permit the fermentation of sugars to products in the presence of 15 mM furfural.
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