A valve with a packing assembly includes a valve body assembly with a bore, a valve member moveable between an open position and a closed position, and a valve stem coupled to the valve member. A first stem packing circumscribes a portion of the valve stem, and is located in an upper bore portion of the bore. A first packing retainer has a collar that limits axial movement of the first stem packing, and also has a first retainer body defining an inner cavity. A second stem packing circumscribes a portion of the valve stem and is located in the inner cavity of the first packing retainer. A second packing retainer has a neck compressingly engaging the second stem packing, and a retainer shoulder that engages the first packing retainer. A retaining assembly is coupled with the valve body assembly for applying axial force to the second packing retainer.