According to one aspect of the present disclosure, a system for communications over multiple protocol interfaces in a computing environment includes a processor and a memory storing interface logic executable by the processor to: identify a first communications protocol of a network interface for egress data packet communications; responsive to the identified first communications protocol of the network interface differing from a second communications protocol to be used for the data packet communications, derive fragmentation data according to a data packet fragmentation protocol corresponding to the second communications protocol; generate an application layer header for the data packet communications; store values of the fragmentation data in select fields of the application layer header; fragment the data packet communications according to the data packet fragmentation protocol; and transmit the data packet communications including the application layer header over the identified network interface.