The invention relates to a compound described by a general formula (1), wherein each X independently can be OPO32−, OPSO22− or OSO3−; R1 comprises a solubility function such as a polyethylene glycol moiety and each X independently can be OPO32−, OPSO22−, − or OSO3−; and Z is an alkyl chain comprising 1 to 3 carbon and/or hetero atoms. The invention further relates to polysulfate derivatives or mixed polyphosphate/sulphate derivatives of six-membered cyclic polyols for use in the therapy of infection by Clostridium difficile.