Invention Grant
US09358249B2 Use of Pateamine A for the treatment of age-related muscle wasting
有权
使用Pateamine A治疗年龄相关的肌肉消瘦
- Patent Title: Use of Pateamine A for the treatment of age-related muscle wasting
- Patent Title (中): 使用Pateamine A治疗年龄相关的肌肉消瘦
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Application No.: US13129539Application Date: 2009-11-18
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Publication No.: US09358249B2Publication Date: 2016-06-07
- Inventor: Jing Huang , Rui Hao , Brett Eugene Lomenick , Nao Jonai , Simon Diep
- Applicant: Jing Huang , Rui Hao , Brett Eugene Lomenick , Nao Jonai , Simon Diep
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Weaver Austin Villeneuve & Sampson LLP
- Agent Tom Hunter
- International Application: PCT/US2009/064964 WO 20091118
- International Announcement: WO2010/059706 WO 20100527
- Main IPC: A61K31/425
- IPC: A61K31/425 ; A61K31/7105
Abstract:
In certain embodiments this invention pertains to the discovery that inhibition of the expression and/or activity of eukaryotic initiation factor 4A (eIF4A) inhibits the aging process. Accordingly, in certain embodiments, methods are provided for inhibiting/slowing aging. The methods typically involve administering to a mammal an agent that inhibits the expression and/or activity of eukaryotic initiation factor 4A (eIF4A) in an amount sufficient to inhibit expression or activity of EIF4A, where the agent is not resveratrol.
Public/Granted literature
- US20110288153A1 TRANSLATION FACTORS AS ANTI-AGING DRUG TARGETS Public/Granted day:2011-11-24
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