Invention Grant
US09358281B2 Methods, agents and peptides for inducing an innate immune response in HIV vaccination
有权
用于在HIV接种中诱导先天免疫应答的方法，试剂和肽
- Patent Title: Methods, agents and peptides for inducing an innate immune response in HIV vaccination
- Patent Title (中): 用于在HIV接种中诱导先天免疫应答的方法，试剂和肽
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Application No.: US12925068Application Date: 2010-10-12
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Publication No.: US09358281B2Publication Date: 2016-06-07
- Inventor: Dan Littman , Nicolas Manel
- Applicant: Dan Littman , Nicolas Manel
- Applicant Address: US NY New York
- Assignee: New York University
- Current Assignee: New York University
- Current Assignee Address: US NY New York
- Agency: Klauber & Jackson LLC
- Main IPC: A61K39/21
- IPC: A61K39/21 ; A61P37/00 ; C12Q1/70 ; G01N33/569 ; C07K14/005 ; A61K39/12 ; A61K39/00
Abstract:
The present invention relates to enhancing, modulating or stimulating the innate immune response to HIV-1 and other viral pathogens and to the modulation and application of immune modulators and peptides for HIV-1 or other pathogen vaccines. The invention provides methods and means to activate an innate response to HIV-1 utilizing or via the HIV capsid protein or peptide, including modulating the binding of cyclophilin A to HIV capsid protein and modulating the ability of HIV to activate the major innate transcription factor IRF3 and interferon. Methods and assays are provided for screening for compounds, agents, or peptides capable of enhancing or activating innate immune response, particularly to HIV-1.
Public/Granted literature
- US20110159025A1 Methods, agents and peptides for inducing an innate immune response in HIV vaccination Public/Granted day:2011-06-30
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