Invention Grant
US09358287B2 Method of treating stress hyperglycemia with human antibodies to the glucagon receptor
有权
用胰高血糖素受体的人抗体治疗应激性高血糖症的方法
- Patent Title: Method of treating stress hyperglycemia with human antibodies to the glucagon receptor
- Patent Title (中): 用胰高血糖素受体的人抗体治疗应激性高血糖症的方法
-
Application No.: US14286606Application Date: 2014-05-23
-
Publication No.: US09358287B2Publication Date: 2016-06-07
- Inventor: Joyce Harp , Haruka Okamoto
- Applicant: Regeneron Pharmaceuticals, Inc.
- Applicant Address: US NY Tarrytown
- Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee Address: US NY Tarrytown
- Agency: Brownstein Hyatt Farber Schreck, LLP
- Agent Cara L. Crowley-Weber; Veronica Mallon
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K45/06 ; A61K38/28 ; C07K16/28 ; C07K16/40 ; A61K39/00

Abstract:
The present invention provides antibodies that bind to the human glucagon receptor, designated GCGR and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human GCGR. The antibodies of the invention are useful for lowering blood glucose levels and blood ketone levels and are also useful for the treatment of diseases and disorders associated with one or more GCGR biological activities, including the treatment of diabetes, diabetic ketoacidosis, long-term complications associated with diabetes, or other metabolic disorders characterized in part by elevated blood glucose levels, including stress hyperglycemia.
Public/Granted literature
- US20140255419A1 Method of Treating Stress Hyperglycemia with Human Antibodies to the Glucagon Receptor Public/Granted day:2014-09-11
Information query