Invention Grant
US09358294B2 Method for formulating a vaccine containing at least two antigens capable of adsorbing onto aluminium oxyhydroxide
有权
用于配制含有至少两种能够吸附在氢氧化铝上的抗原的疫苗的方法
- Patent Title: Method for formulating a vaccine containing at least two antigens capable of adsorbing onto aluminium oxyhydroxide
- Patent Title (中): 用于配制含有至少两种能够吸附在氢氧化铝上的抗原的疫苗的方法
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Application No.: US14372695Application Date: 2013-01-17
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Publication No.: US09358294B2Publication Date: 2016-06-07
- Inventor: Landry Bertaux , Isabelle Chacornac , Alain Françon , Jean-François Hau , Sandrine Lentsch Graf
- Applicant: Sanofi Pasteur
- Applicant Address: FR Iyon
- Assignee: SANOFI PASTEUR
- Current Assignee: SANOFI PASTEUR
- Current Assignee Address: FR Iyon
- Agency: Proskauer Rose LLP
- Agent Fangli Chen
- Priority: FR1250464 20120117
- International Application: PCT/FR2013/050106 WO 20130117
- International Announcement: WO2013/107988 WO 20130725
- Main IPC: A61K39/385
- IPC: A61K39/385 ; A61K47/02 ; A61K39/12 ; A61K39/102 ; A61K39/29 ; C12N7/00 ; A61K39/05 ; A61K39/08 ; A61K39/02 ; A61K39/00
Abstract:
The subject matter of the invention is a method for preparing a vaccine composition comprising at least aluminum oxyhydroxide (AlOOH), and at least the hepatitis B surface antigen and the Haemophilus influenzae type b antigen. According to the invention, the hepatitis B surface antigen is kept adsorbed on the AlOOH, whereas the Hib antigen is kept nonadsorbed. To this end: the hepatitis B surface antigen is adsorbed onto AlOOH in order to obtain an AlOOH/HBsAg complex, then—said AlOOH/HBsAg complex is mixed with the Hib antigen in the presence of cationic amino acids at a concentration of at least 100 mg/l, and of phosphate ions at a concentration of 35 to 45 mMol/l.
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