Configuration of advertisements in a streaming video segment from a serving node is based on a result of an interactive game process executing on a client device. A configuration of advertisements in the streaming video is determined based on the game result. The configuration may include which advertisements are selected to play during ad slots to be included in the video segment, or a number of ad slots to be provided in the video segment. The serving node may configure the video segment with the advertisements selected based on the game result in the determined number of ad slots so that the selected advertisements are played during the ad slots when the video segment is streamed to the client device. If the video segment is configured with no ad slots based on the game result, then the video segment may be streamed to the client device without advertisements.