Invention Grant
US09359298B2 Cajanine structure analogous compound, preparation method and use
有权
卡氨酸结构类似化合物，制备方法和用途
- Patent Title: Cajanine structure analogous compound, preparation method and use
- Patent Title (中): 卡氨酸结构类似化合物，制备方法和用途
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Application No.: US14368066Application Date: 2012-12-18
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Publication No.: US09359298B2Publication Date: 2016-06-07
- Inventor: Zhuorong Li , Xingyue Ji , Situ Xue , Guanghui Zheng , Yuhuan Li , Peizhen Tao , Jiandong Jiang
- Applicant: INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES
- Applicant Address: CN Beijing
- Assignee: INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES
- Current Assignee: INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES
- Current Assignee Address: CN Beijing
- Agency: Rankin, Hill & Clark LLP
- Priority: CN201110439374 20111223
- International Application: PCT/CN2012/001711 WO 20121218
- International Announcement: WO2013/091282 WO 20130627
- Main IPC: C07D213/30
- IPC: C07D213/30 ; C07D213/68 ; C07D213/55 ; C07D213/64 ; C07D213/65 ; C07D213/69 ; C07C65/28 ; C07C69/92 ; C07C51/09 ; C07C65/105 ; C07C65/19 ; C07C43/215 ; C07C43/23 ; C07D213/80 ; C07D311/58 ; C07C275/00 ; C07C275/54 ; C07C279/22 ; C07C281/02 ; C07D333/16 ; C07D333/24 ; C07D233/60 ; C07D233/90 ; C07C217/20 ; C07C217/22 ; C07D241/04 ; C07C229/08 ; C07C235/46 ; C07C235/62 ; C07C235/64 ; C07D207/16 ; C07D211/58 ; C07C69/157 ; C07C69/36 ; C07C39/21 ; C07C51/353 ; C07C51/36 ; C07C41/18 ; C07C67/30 ; C07C231/12
Abstract:
Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided are pharmaceutical compositions containing the compounds as active ingredient, and uses thereof; the compounds of the present invention having the pharmacological activities such as anti-virus, anti-virus-infection, nerve protection, anti-metabolic-diseases and the like. Also provided is a chemical total synthesis preparation method of the natural products cajanine, cajanine A and cajanine C. The present invention lays a foundation for the in-depth study and development of the compounds as clinical drugs in the future.
Public/Granted literature
- US20140371232A1 CAJANINE STRUCTURE ANALOGOUS COMPOUND, PREPARATION METHOD AND USE Public/Granted day:2014-12-18
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