Invention Grant
- Patent Title: Small molecules for treating breast cancer
- Patent Title (中): 用于治疗乳腺癌的小分子
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Application No.: US14009969Application Date: 2012-04-04
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Publication No.: US09359299B2Publication Date: 2016-06-07
- Inventor: Sivanesan Dakshanamurthy , Milton L. Brown , Robert Clarke , Ayesha N. Shajahan-Haq , Jacqueline Smith
- Applicant: Sivanesan Dakshanamurthy , Milton L. Brown , Robert Clarke , Ayesha N. Shajahan-Haq , Jacqueline Smith
- Applicant Address: US DC Washington
- Assignee: Georgetown University
- Current Assignee: Georgetown University
- Current Assignee Address: US DC Washington
- Agency: Kilpatrick Townsend & Stockton, LLP
- International Application: PCT/US2012/032110 WO 20120404
- International Announcement: WO2012/138715 WO 20121011
- Main IPC: C07D213/32
- IPC: C07D213/32 ; A61K31/4439 ; A61K45/06 ; C07D401/04 ; C07D401/14 ; C07D405/14 ; C07D417/04 ; C07D417/14 ; A61K31/41 ; A61K31/426 ; A61K31/427 ; A61K31/444
Abstract:
Small molecule inhibitors of XBP1 splicing by IRE1 are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.
Public/Granted literature
- US20140088148A1 SMALL MOLECULE INHIBITORS OF XBP1 SPLICING Public/Granted day:2014-03-27
Information query
