Invention Grant
US09359300B2 Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds
有权
甲基/二氟苯基甲氧基取代的吡啶酮 - 吡啶基化合物，甲基 - 吡啶基 - 甲氧基取代的吡啶酮 - 吡啶基化合物和甲基 - 嘧啶基 - 甲氧基取代的吡啶酮 - 吡啶基化合物
- Patent Title: Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds
- Patent Title (中): 甲基/二氟苯基甲氧基取代的吡啶酮 - 吡啶基化合物，甲基 - 吡啶基 - 甲氧基取代的吡啶酮 - 吡啶基化合物和甲基 - 嘧啶基 - 甲氧基取代的吡啶酮 - 吡啶基化合物
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Application No.: US13913350Application Date: 2013-06-07
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Publication No.: US09359300B2Publication Date: 2016-06-07
- Inventor: Shaun R. Selness , Joseph B. Monahan , John F. Schindler , Balekudru Devadas , Susan L. Hockerman
- Applicant: CONFLUENCE LIFE SCIENCES INC.
- Applicant Address: US MO St. Louis
- Assignee: CONFLUENCE LIFE SCIENCES, INC.
- Current Assignee: CONFLUENCE LIFE SCIENCES, INC.
- Current Assignee Address: US MO St. Louis
- Agency: Harness, Dickey & Pierce, P.L.C.
- Main IPC: C07D401/14
- IPC: C07D401/14 ; A61K31/4412 ; C07D213/69 ; A61K31/506 ; A61K45/06 ; A61K31/444
Abstract:
The present disclosure provides methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3 and X are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.
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