Invention Grant
- Patent Title: Ethynyl derivatives
- Patent Title (中): 乙炔衍生物
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Application No.: US14689387Application Date: 2015-04-17
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Publication No.: US09359301B2Publication Date: 2016-06-07
- Inventor: Georg Jaeschke , Lothar Lindemann , Antonio Ricci , Daniel Rueher , Heinz Stadler , Eric Vieira
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Little Falls
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Little Falls
- Agent Tamara A. Kale
- Priority: EP12188943 20121018
- Main IPC: A61K31/506
- IPC: A61K31/506 ; C07D213/81 ; C07D239/28

Abstract:
The present invention relates to ethynyl derivatives of formula I wherein Y is N or CH R1 is fluoro or chloro or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. It has now surprisingly been found that the compounds of general formula I are metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of anxiety and pain, depression, Fragile-X syndrom, autism spectrum disorders, Parkinson's disease, and gastroesophageal reflux disease (GERD).
Public/Granted literature
- US20150225345A1 Ethynyl Derivatives Public/Granted day:2015-08-13
Information query
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