Invention Grant
US09359313B2 Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator
有权
二甲双胍与葡萄糖激酶活化剂和包含二甲双胍和葡糖激酶活化剂的组合物的组合使用
- Patent Title: Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator
- Patent Title (中): 二甲双胍与葡萄糖激酶活化剂和包含二甲双胍和葡糖激酶活化剂的组合物的组合使用
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Application No.: US13114964Application Date: 2011-05-24
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Publication No.: US09359313B2Publication Date: 2016-06-07
- Inventor: Adnan M. M. Mjalli , Maria Carmen Valcarce Lopez
- Applicant: Adnan M. M. Mjalli , Maria Carmen Valcarce Lopez
- Applicant Address: US NC High Point
- Assignee: vTv Therapeutics LLC
- Current Assignee: vTv Therapeutics LLC
- Current Assignee Address: US NC High Point
- Agent Samuel B. Rollins
- Main IPC: A61K31/425
- IPC: A61K31/425 ; A61K31/155 ; C07D277/54
Abstract:
The present invention provides uses of a glucokinase activator in combination with metformin. Uses include treating type 2 diabetes, lowering blood glucose, improving insulin sensitivity, enhancing phosphorylation of glucose, and improving the therapeutic effectiveness of metformin. The invention also provides pharmaceutical compositions that comprise a GK activator and metformin. The invention also provides a salt formed between metformin and a GK activator.
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