Invention Grant
- Patent Title: Efficient process for the preparation of Lapatinib and salts thereof by means of new intermediates
- Patent Title (中): 通过新中间体制备拉帕替尼及其盐的有效方法
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Application No.: US14804828Application Date: 2015-07-21
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Publication No.: US09359333B2Publication Date: 2016-06-07
- Inventor: Francesco Fontana , Alfredo Paio
- Applicant: F.I.S.—Fabbrica Italiana Sintetici S.p.A.
- Applicant Address: IT Montecchio Maggiore
- Assignee: F.I.S.—Fabbrica Italiana Sintetiei
- Current Assignee: F.I.S.—Fabbrica Italiana Sintetiei
- Current Assignee Address: IT Montecchio Maggiore
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Priority: ITVI2013A0003 20130114; ITVI2013A0086 20130328
- Main IPC: C07D405/14
- IPC: C07D405/14 ; C07D405/04 ; C07C309/30
Abstract:
The present invention refers to a new efficient process for the synthesis of the active pharmaceutical ingredient Lapatinib and salts thereof.In particular, the present synthesis is carried out employing new intermediates in which the amine function is protected by a group cleavable in basic milieu that provides a higher overall yield of the synthesis process.
Public/Granted literature
- US20150322050A1 Efficient Process for the Preparation of Lapatinib and Salts Thereof by Means of New Intermediates Public/Granted day:2015-11-12
Information query
