Invention Grant
US09359340B2 Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors
有权
羟基化和甲氧基化的嘧啶基环戊烷作为Akt蛋白激酶抑制剂
- Patent Title: Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors
- Patent Title (中): 羟基化和甲氧基化的嘧啶基环戊烷作为Akt蛋白激酶抑制剂
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Application No.: US14458062Application Date: 2014-08-12
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Publication No.: US09359340B2Publication Date: 2016-06-07
- Inventor: Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik , Eli M. Wallace , Stephen T. Schlachter , Anna L. Leivers , Jun Liang , Brian Safina , Birong Zhang , Christine Chabot , Steven Do
- Applicant: Array BioPharma Inc. , Genentech, Inc.
- Applicant Address: US CO Boulder US CA South San Francisco
- Assignee: Array BioPharma Inc.,Genentech, Inc.
- Current Assignee: Array BioPharma Inc.,Genentech, Inc.
- Current Assignee Address: US CO Boulder US CA South San Francisco
- Agency: Viksnins Harris & Padys PLLP
- Main IPC: C07D239/70
- IPC: C07D239/70 ; C07D403/04 ; C07D413/12 ; C07D401/12 ; C07D403/12 ; C07D405/12 ; C07D409/12 ; C07D409/14 ; C07D407/12 ; A61P29/00 ; A61P35/00 ; A61P9/00 ; A61P25/28 ; A61P15/00 ; A61P17/00 ; A61K31/517 ; A61K31/496
Abstract:
The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Public/Granted literature
- US20160152606A9 HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS Public/Granted day:2016-06-02
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