Invention Grant
- Patent Title: Identification of compounds that disperse TDP-43 inclusions
- Patent Title (中): 鉴定分散TDP-43夹杂物的化合物
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Application No.: US14118628Application Date: 2012-05-21
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Publication No.: US09359363B2Publication Date: 2016-06-07
- Inventor: Benjamin Wolozin , Marcie Glicksman , Gregory D. Cuny , Justin Boyd
- Applicant: Benjamin Wolozin , Marcie Glicksman , Gregory D. Cuny , Justin Boyd
- Applicant Address: US MA Newton US MA Boston
- Assignee: AQUINNAH PHARMACEUTICALS, INC.,THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- Current Assignee: AQUINNAH PHARMACEUTICALS, INC.,THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- Current Assignee Address: US MA Newton US MA Boston
- Agency: Lando & Anastasi, LLP
- International Application: PCT/US2012/038861 WO 20120521
- International Announcement: WO2012/162249 WO 20121129
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D207/36 ; C07D211/26 ; C07D211/52 ; C07D215/227 ; C07D215/36 ; C07D239/52 ; C07D239/94 ; C07D401/04 ; C07D401/12 ; C07D403/06 ; C07D417/04 ; A61P25/28 ; A61K31/4025 ; A61K31/445 ; A61K31/454 ; A61K31/4545 ; A61K31/47 ; A61K31/505 ; A61K31/517 ; A61K31/519 ; A61K31/551 ; A61K31/365 ; A61K31/704 ; C07D211/34 ; G01N33/50
Abstract:
Herein, methods of modulating inclusion formation and stress granules in cells are described. The methods comprise contacting a cell with an inclusion inhibitor. Methods for screening for modulators of TDP-43 aggregation are also described.
Public/Granted literature
- US20140080780A1 identification of compounds that disperse tdp-43 inclusions Public/Granted day:2014-03-20
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