Invention Grant
- Patent Title: Intermediate of Ticagrelor and preparation method therefor, and preparation method for Ticagrelor
- Patent Title (中): 替卡格雷中间体及其制备方法及替卡格雷的制备方法
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Application No.: US14781803Application Date: 2014-03-13
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Publication No.: US09359366B2Publication Date: 2016-06-07
- Inventor: Shaoguang Sun , Defu Song , Biao He , Xiaobo Lai
- Applicant: Jiangsu Hengrui Medicine Co., Ltd. , Suncadia Pharmaceuticals Co., Ltd.
- Applicant Address: CN Lianyungang, Jiangsu CN Chengdu, Sichuan
- Assignee: Jiangsu Hengrui Medicine Co., Ltd.,Suncadia Pharmaceuticals Co., Ltd.
- Current Assignee: Jiangsu Hengrui Medicine Co., Ltd.,Suncadia Pharmaceuticals Co., Ltd.
- Current Assignee Address: CN Lianyungang, Jiangsu CN Chengdu, Sichuan
- Agency: Panitch Schwarze Belisario & Nadel LLP
- Priority: CN201310122613 20130410; CN201310383474 20130828
- International Application: PCT/CN2014/073388 WO 20140313
- International Announcement: WO2014/166324 WO 20141016
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D405/12 ; C07D239/48 ; C07D239/47

Abstract:
Disclosed are intermediates of Ticagrelor and a preparation method therefor, and a preparation method for Ticagrelor. Specifically, disclosed is an intermediate, namely, a compound of Formula (VI), for preparing Ticagrelor. Further disclosed is a method for preparing the intermediate and a method for preparing Ticagrelor by using the intermediate. Ticagrelor is prepared by using the intermediate, so that the synthesis process is simple, and a defect that long reaction times under high temperature that are required in the existing methods are avoided. The method is suitable for mass production in industry, energy consumption is reduced, pollution of the environment is reduced, and discharge of waste is reduced.
Public/Granted literature
- US20160052928A1 INTERMEDIATE OF TICAGRELOR AND PREPARATION METHOD THEREFOR, AND PREPARATION METHOD FOR TICAGRELOR Public/Granted day:2016-02-25
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