Invention Grant
- Patent Title: Icotinib hydrochloride, synthesis, crystalline forms, pharmaceutical compositions, and uses thereof
- Patent Title (中): 盐酸伊替替，合成，结晶形式，药物组合物及其用途
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Application No.: US14448070Application Date: 2014-07-31
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Publication No.: US09359370B2Publication Date: 2016-06-07
- Inventor: Yinxiang Wang , Guojian Xie , Lieming Ding , Fenlai Tan , Yunyan Hu , Wei He , Bin Han , Wei Long , Yong Liu , Haima Ai , Charles Davis , Don Zhang
- Applicant: Beta Pharma, Inc.
- Applicant Address: US NJ Princeton
- Assignee: Beta Pharma, Inc.
- Current Assignee: Beta Pharma, Inc.
- Current Assignee Address: US NJ Princeton
- Agency: Fox Rothschild, LLP
- Agent Wansheng Jerry Liu
- Priority: CN200810132631 20080708; CN200810132458 20080717; CN200810188272 20081223
- Main IPC: C07D491/056
- IPC: C07D491/056 ; A61K31/519
Abstract:
The invention relates to 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, its therapeutic usage for treatment of diseases mediated by EGFR kinase and its combinatory therapeutic usage together with other therapeutic agents. The invention also provides synthetic methods for preparation of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, and the relevant synthetic intermediates for synthesis of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride.
Public/Granted literature
- US20140343082A1 ICOTINIB HYDROCHLORIDE, SYNTHESIS, CRYSTALLINE FORMS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Public/Granted day:2014-11-20
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