Invention Grant
- Patent Title: Site-specific chemoenzymatic protein modifications
- Patent Title (中): 位点特异性化疗酶蛋白修饰
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Application No.: US14329758Application Date: 2014-07-11
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Publication No.: US09359400B2Publication Date: 2016-06-07
- Inventor: Aimee Usera , Zachary Robinson , Jennifer Cobb
- Applicant: Aimee Usera , Zachary Robinson , Jennifer Cobb
- Applicant Address: CH
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH
- Agency: Brinks Gilson & Lione
- Agent Ryan L. Marshall
- Main IPC: C07K5/103
- IPC: C07K5/103 ; A61K49/00 ; A61K47/48 ; C07K5/083 ; C07K5/062 ; C07K1/13 ; C07D209/42 ; C07K7/02 ; C07K5/072 ; C07C271/22 ; C07C317/28 ; A61K38/06 ; A61K38/05 ; A61K38/07
Abstract:
The present invention relates to methods and reagents for use in site-selective modification of proteins having lysine residues with functionalized peptides using a chemoenzymatic microbial transglutaminase-mediated reaction. The functionalized proteins may be used for study or therapeutic uses.
Public/Granted literature
- US20150017192A1 SITE-SPECIFIC CHEMOENZYMATIC PROTEIN MODIFICATIONS Public/Granted day:2015-01-15
Information query
