Invention Grant
- Patent Title: Single chain relaxin polypeptides
- Patent Title (中): 单链松弛素多肽
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Application No.: US13821726Application Date: 2011-09-08
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Publication No.: US09359422B2Publication Date: 2016-06-07
- Inventor: Karl Johan Rosengren , Linda Maria Haugaard-Kedstrom , Ross Alexander David Bathgate , Mohammed Akhter Hossain , John Desmond Wade , Andrew Lawrence Gundlach , Andrew J. Lawrence
- Applicant: Karl Johan Rosengren , Linda Maria Haugaard-Kedstrom , Ross Alexander David Bathgate , Mohammed Akhter Hossain , John Desmond Wade , Andrew Lawrence Gundlach , Andrew J. Lawrence
- Applicant Address: AU Queensland AU Parkville, Victoria
- Assignee: The University of Queensland,Howard Florey Institute of Experimental Physiology and Medicine
- Current Assignee: The University of Queensland,Howard Florey Institute of Experimental Physiology and Medicine
- Current Assignee Address: AU Queensland AU Parkville, Victoria
- Agency: Wilson Sonsini Goodrich & Rosati
- Priority: AU2010904046 20100908
- International Application: PCT/AU2011/001158 WO 20110908
- International Announcement: WO2012/031326 WO 20120315
- Main IPC: C07K14/64
- IPC: C07K14/64 ; A61K38/22 ; C07H21/04 ; C07K14/575 ; A61K38/00
Abstract:
The present invention relates to biologically active single chain relaxin polypeptides comprising a relaxin B chain derived from relaxin-3, the polypeptides being truncated by one or more amino acids at the C-terminus of the relaxin-3 B chain. Typically the single chain relaxin polypeptides are antagonists of the RXFP3 receptor, and in some embodiments are selective antagonists of the RXFP3 receptor.
Public/Granted literature
- US20140038895A1 Single Chain Relaxin Polypeptides Public/Granted day:2014-02-06
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