Invention Grant
- Patent Title: Mutant MT-SP1 proteases with altered substrate specificity or activity
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Application No.: US13986644Application Date: 2013-05-20
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Publication No.: US09359598B2Publication Date: 2016-06-07
- Inventor: Sandra Waugh Ruggles , Jack Nguyen
- Applicant: CATALYST BIOSCIENCES, INC.
- Applicant Address: US CA South San Francisco
- Assignee: Catalyst Biosciences, Inc.
- Current Assignee: Catalyst Biosciences, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Dentons US LLP
- Agent Stephanie Seidman
- Main IPC: C12N9/50
- IPC: C12N9/50 ; C12N9/64

Abstract:
MT-SP1 mutein proteases with altered specificity for the target molecules they cleave can be used to treat human diseases, such as cancer. Cleaving VEGF or VEGFR at certain substrate sequences with wild-type and mutein MT-SP1 proteases can be used to treat pathologies associated with angiogenesis.
Public/Granted literature
- US20140030791A1 Mutant MT-SP1 proteases with altered substrate specificity or activity Public/Granted day:2014-01-30
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