Invention Grant
- Patent Title: Permuted and nonpermuted luciferase biosensors
- Patent Title (中): 有色和非精子萤光素酶生物传感器
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Application No.: US11732105Application Date: 2007-04-02
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Publication No.: US09359635B2Publication Date: 2016-06-07
- Inventor: Brock Binkowski , Frank Fan , Susan Wigdal , Keith V. Wood , Monika G. Wood
- Applicant: Brock Binkowski , Frank Fan , Susan Wigdal , Keith V. Wood , Monika G. Wood
- Applicant Address: US WI Madison
- Assignee: PROMEGA CORPORATION
- Current Assignee: PROMEGA CORPORATION
- Current Assignee Address: US WI Madison
- Agency: Michael Best & Friedrich LLP
- Main IPC: C12N9/02
- IPC: C12N9/02 ; C07H21/04 ; C12N15/00 ; C12N1/20 ; C12N1/00 ; C12Q1/66
Abstract:
A modified luciferase protein which is a sensor for molecules including cAMP, cGMP, calcium, chelators thereof, kinases, or phosphatases is provided. Also provided is a circularly permuted anthozoan luciferase protein and a decapod crustacean luciferase protein, optionally containing one or more heterologous amino acid sequences, at least one of which directly or indirectly interacts with a molecule of interest. Further provided is a modified anthozoan luciferase protein and a decapod crustacean luciferase protein containing an insertion of one or more heterologous amino acid sequences, at least one of which directly or indirectly interacts with a molecule of interest.
Public/Granted literature
- US20110039257A1 Permuted and nonpermuted luciferase biosensors Public/Granted day:2011-02-17
Information query
