Systems, computer readable media, and program code for systematically providing enhanced energy efficiency of mega industrial sites and synergy with the adjacent community through advanced hybrid inter-systems energy integration targeting and solutions generation to achieve desired best levels of energy consumption and greenhouse gas emissions reduction, are provided. An exemplary system includes a computer and computer readable code for performing the operations of determining possible inter-processes integration energy consumption targets, selecting an energy-efficient inter-processes integration energy consumption target, determining the inter-processes energy integration combination providing for the energy efficient inter-processes integration energy consumption target, generating a plurality of technically viable industrial site inter-processes heat exchange system design alternatives, and assisting a user to identify the technically viable industrial site inter-processes heat exchange system design substantially providing for optimal total waste heat recovery between the respective functional areas.