Dynamic reconfiguration of queue pairs in a data processing system is provided. A device driver determines whether a dynamic CPU reconfiguration has added one or more CPUs to the data processing system, wherein the data processing system comprises a number of CPUs and a number of queue pairs. Responsive to the dynamic CPU configuration adding one or more CPUs, the device driver allocates a portion of a memory corresponding to a queue pair, wherein each queue pair comprises a receive queue and a transmit queue, programs a receive side scaling mechanism in a network adapter to allow for dynamic insertion of a processing engine associated with the queue pair, and enables transmit tuple hashing to the queue pair.