Invention Grant
- Patent Title: Vectors for generating pluripotent stem cells and methods of producing pluripotent stem cells using the same
- Patent Title (中): 用于产生多能干细胞的载体和使用其制备多能干细胞的方法
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Application No.: US13292953Application Date: 2011-11-09
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Publication No.: US09365866B2Publication Date: 2016-06-14
- Inventor: Mahito Nakanishi , Ken Nishimura , Masayuki Sano , Manami Ohtaka
- Applicant: Mahito Nakanishi , Ken Nishimura , Masayuki Sano , Manami Ohtaka
- Applicant Address: JP Tokyo
- Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
- Current Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
- Current Assignee Address: JP Tokyo
- Agency: Sughrue Mion, PLLC
- Priority: WOPCT/JP2010/058368 20100518; JP2010-250993 20101109
- Main IPC: C12N15/63
- IPC: C12N15/63 ; C12N7/01 ; C12N15/864 ; C12N5/0789 ; C12N15/86 ; C12N5/074 ; C12N15/113 ; C12N15/877
Abstract:
A reprogramming gene-loaded Sendai viral vector comprising Sendai virus genes and reprogramming genes, wherein the Sendai virus genes include an NP gene, P/C gene, M gene, F gene, HN gene and L gene, wherein each of the M gene, the F gene and the FIN gene is from a Sendai virus strain Cl.151-derived gene and wherein at least one of the M gene, the F gene and the HN gene is functionally deleted and the L gene encodes the amino-acid sequence of the L protein in which the amino-acid residue at position 1618 is valine and a method of producing the same.
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