The present invention provides a multi-channel time-interleaved analog-to-digital converter, including: a clock generation circuit, configured to generate a work clock of the analog-to-digital converter; a channel ADC group, including M ADC channels, and configured to convert, under the control of the clock generation circuit and in a time division multiplexing manner, one high-speed analog input signal into M low-speed digital output signals; a channel mismatch detection circuit, configured to detect in real time timing skew errors of output signals of the M ADC channels; a signal compensation and reconstruction circuit, configured to perform, according to the timing skew parameters detected, compensation and reconstruction on the digital output signals output by the channel ADC group; and a signal combining circuit, configured to combine the M low-speed output signals that are of the channels and generated after the compensation by the signal compensation and reconstruction circuit.