Invention Grant
US09381203B2 Combination therapies for treatment of laminopathies, cellular aging, and atherosclerosis
有权
用于治疗薄层病，细胞衰老和动脉粥样硬化的联合疗法
- Patent Title: Combination therapies for treatment of laminopathies, cellular aging, and atherosclerosis
- Patent Title (中): 用于治疗薄层病，细胞衰老和动脉粥样硬化的联合疗法
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Application No.: US14209197Application Date: 2014-03-13
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Publication No.: US09381203B2Publication Date: 2016-07-05
- Inventor: Leslie B. Gordon , Mark W. Kieran , Monica E. Kleinman
- Applicant: Leslie B. Gordon , Mark W. Kieran , Monica E. Kleinman
- Agency: JMB Davis Ben-David
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/675 ; A61K31/21 ; A61K31/4545 ; A61K31/22 ; A61K31/436 ; A61K45/06 ; A61K31/55 ; A61K31/663
Abstract:
Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin, and inhibit farnesyl biosynthesis, lamin A prenylation, and increase progerin clearance.
Public/Granted literature
- US20140274964A1 COMBINATION THERAPIES FOR TREATMENT OF LAMINOPATHIES, CELLULAR AGING, AND ATHEROSCLEROSIS Public/Granted day:2014-09-18
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