Invention Grant
US09381247B2 Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain
有权
用于调节胰岛素和胰岛素类似物的药代动力学和药效学的镁组合物和注射部位疼痛
- Patent Title: Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain
- Patent Title (中): 用于调节胰岛素和胰岛素类似物的药代动力学和药效学的镁组合物和注射部位疼痛
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Application No.: US13826806Application Date: 2013-03-14
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Publication No.: US09381247B2Publication Date: 2016-07-05
- Inventor: Roderike Pohl , Robert Hauser , Ming Li , Bryan R. Wilson
- Applicant: Biodel Inc.
- Applicant Address: US CT Danbury
- Assignee: Biodel Inc.
- Current Assignee: Biodel Inc.
- Current Assignee Address: US CT Danbury
- Agency: Pabst Patent Group LLP
- Main IPC: A61K47/02
- IPC: A61K47/02 ; A61K38/28 ; A61K9/00 ; A61K47/12 ; A61K47/18

Abstract:
Compositions and methods for modulating injection site pain associated with rapid acting injectable insulin formulations have been developed for subcutaneous injection. The formulations contain insulin in combination with a zinc chelator such as ethylenediaminetetraacetic acid (“EDTA”), a dissolution/stabilization agent such as citric acid, a magnesium salt, and, optionally, additional excipients. New presentations include rapid acting concentrated insulin formulations and a way to enhance the absorption of commercially available rapid acting analog formulations by mixing them with a vial containing dry powder excipients that accelerate their absorption. Devices for mixing excipient and insulin together at the time of administration, while minimizing residence time of the mixture, are also described.
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