An apparatus for more accurately stimulating a living body comprises: a stimulation unit configured to apply a bio-stimulation signal in vicinity to a living body, the bio-stimulation signal being composed of pieces of time-series data having a specific frequency; and a control unit configured to derive bio-stimulation information required to achieve targeted bio-information using time space data indicative of bio-responses interacting at a plurality of different positions in response to the bio-stimulation signal, and derive a relation between the bio-stimulation signal and the bio-responses, and control the stimulation unit to apply the bio-stimulation signal in response to the derived bio-stimulation information. The relation is configured to set the bio-stimulation information as variables in an X matrix (m, t), set the bio-response information as variables in a Y matrix (n, t), and derive an A matrix (n, m) satisfying Y=AX.