Invention Grant
US09382203B2 N-carbamoylmethyl-4-(R)-phenyl-2-pyrrolidinone, method of its preparation and pharmaceutical use
有权
N-氨基甲酰基甲基-4-（R） - 苯基-2-吡咯烷酮，其制备方法和药物用途
- Patent Title: N-carbamoylmethyl-4-(R)-phenyl-2-pyrrolidinone, method of its preparation and pharmaceutical use
- Patent Title (中): N-氨基甲酰基甲基-4-（R） - 苯基-2-吡咯烷酮，其制备方法和药物用途
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Application No.: US14688633Application Date: 2015-04-16
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Publication No.: US09382203B2Publication Date: 2016-07-05
- Inventor: Grigory Veinberg , Maksim Vorona , Liga Zvejniece , Aleksandrs Chernobrovijs , Ivars Kalvinsh , Ligita Karina , Maija Dambrova
- Applicant: Joint Stock Company (JSC) “OLAINFARM”
- Applicant Address: LV Olain
- Assignee: JOINT STOCK COMPANY (JSC) “OLAINFARM”
- Current Assignee: JOINT STOCK COMPANY (JSC) “OLAINFARM”
- Current Assignee Address: LV Olain
- Agency: Caesar Rivise, PC
- Priority: LVP-06-24 20060316; EPPCT/EP2007/052424 20070315
- Main IPC: A61K31/4015
- IPC: A61K31/4015 ; C07D207/27
Abstract:
The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence of a strong base and the treatment of intermediate N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone with ammonia.
Public/Granted literature
- US20150216846A1 N-Carbamoylmethyl-4-(R)-Phenyl-2-Pyrrolidinone, Method of its Preparation and Pharmaceutical Use Public/Granted day:2015-08-06
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