Invention Grant
US09382204B2 Inhibitors targeting the DNA-binding domain of human STAT3 for treatment of metastatic cancers
有权
靶向人STAT3的DNA结合结构域的抑制剂用于治疗转移性癌症
- Patent Title: Inhibitors targeting the DNA-binding domain of human STAT3 for treatment of metastatic cancers
- Patent Title (中): 靶向人STAT3的DNA结合结构域的抑制剂用于治疗转移性癌症
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Application No.: US14496384Application Date: 2014-09-25
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Publication No.: US09382204B2Publication Date: 2016-07-05
- Inventor: Jian-Ting Zhang
- Applicant: Jian-Ting Zhang
- Applicant Address: US IN Indianapolis
- Assignee: Indiana University Research and Technology Corporation
- Current Assignee: Indiana University Research and Technology Corporation
- Current Assignee Address: US IN Indianapolis
- Agency: Quarles & Brady LLP
- Main IPC: C07D207/44
- IPC: C07D207/44
Abstract:
The present invention provides STAT3 inhibitors which preferentially suppress proliferation of cancer over non-cancer cells and inhibit migration and invasion of malignant cells. The inhibitors of the present invention selectively inhibit STAT3 binding to DNA without affecting the activation and dimerization of STAT3. Furthermore, the inhibitors of the present invention inhibit expression of STAT3 downstream target genes and STAT3 binding to chromatin in situ.
Public/Granted literature
- US20150094353A1 Inhibitors Targeting the DNA-Binding Domain of Human STAT3 for Treatment of Metastatic Cancers Public/Granted day:2015-04-02
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