Invention Grant
- Patent Title: Aldosterone synthase inhibitors
- Patent Title (中): 醛固酮合酶抑制剂
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Application No.: US13811059Application Date: 2011-07-20
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Publication No.: US09382226B2Publication Date: 2016-07-05
- Inventor: Scott B. Hoyt , Min K. Park , Clare London , Yusheng Xiong , D. Jonathan Bennett , Jiaqiang Cai , Paul Ratcliffe , Andrew Cooke , Emma Carswell , John MacLean , Rohit Saxena , Bheemashankar A. Kulkarni , Archana Gupta
- Applicant: Scott B. Hoyt , Min K. Park , Clare London , Yusheng Xiong , D. Jonathan Bennett , Jiaqiang Cai , Paul Ratcliffe , Andrew Cooke , Emma Carswell , John MacLean , Rohit Saxena , Bheemashankar A. Kulkarni , Archana Gupta
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Janet E. Fair; Anna L. Cocuzzo
- International Application: PCT/US2011/044598 WO 20110720
- International Announcement: WO2012/012478 WO 20120126
- Main IPC: C07D401/04
- IPC: C07D401/04 ; C07D413/14 ; C07D471/04 ; A61K31/4375 ; A61K31/4439 ; A61K31/4184 ; A61K31/4709
Abstract:
The invention involves compounds of structural Formula (I) and the pharmaceutically acceptable salts thereof. The compounds of the invention are effective at selectively inhibiting CYP11B2, and are therefore useful for the treatment or prophylaxis of disorders that are associated with elevated aldosterone levels, including, but not limited to, hypertension and heart failure.
Public/Granted literature
- US20130317057A1 ALDOSTERONE SYNTHASE INHIBITORS Public/Granted day:2013-11-28
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