Invention Grant
- Patent Title: Cyclic depsipeptide compounds and their uses
- Patent Title (中): 环状三肽类化合物及其用途
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Application No.: US14433327Application Date: 2013-10-02
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Publication No.: US09382295B2Publication Date: 2016-07-05
- Inventor: Hans Georg Fliri , Rhonan Lee Ford , Antonio Kuok Keong Vong
- Applicant: Cypralis Limited
- Applicant Address: GB Ongar, Essex
- Assignee: Cypralis Limited
- Current Assignee: Cypralis Limited
- Current Assignee Address: GB Ongar, Essex
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Mei Bai
- Priority: GB1217560.0 20121002
- International Application: PCT/GB2013/052570 WO 20131002
- International Announcement: WO2014/053834 WO 20140410
- Main IPC: A61K38/12
- IPC: A61K38/12 ; C07K11/02 ; C07K7/56 ; A61K38/00
Abstract:
The present invention relates to novel cycloundecadepsipeptide compounds and their analoges which bind and inhibit cyclophilins, have reduced immunosuppressive activity and improved physicochemical properties including water solubility. The present invention further relates to pharmaceutical compositions containing said depsipeptide compounds and their analoges for use in the treatment or prevention of diseases and pathologies which may be ameliorated by the inhibition of cyclophilin activity.
Public/Granted literature
- US20150259386A1 CYCLIC DEPSIPEPTIDE COMPOUNDS AND THEIR USES Public/Granted day:2015-09-17
Information query
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